|1918 FLU VIRUS HAD THE POWER TO TURN THE HUMAN BODY TO DESTROY ITSELF....AND THUS SO EASILY KILLED 50 MILLION PEOPLE IN THE WORLD IN LESS THAN A YEAR.|
Posted by Vishva News Reporter on November 12, 2007
SECRET OF CREATION OF
....IT IS GENES..
BUT WHAT MAKES GENES COME ALIVE?
1918 FLU KILLING 50 MILLION PEOPLE
REVEALS CREATION OF LIFE
AND TAKING OF LIFE
In the second only of its kind laboratory
in the world, the Canada's National Microbiology Laboratory in Winnipeg,
Manitoba, with Level 4 biosafety certification,
eight carefully crafted genes were inserted into cells along with a few
proteins. Within hours, the cells were taking instructions from the
inserted genes and mass-producing copies of the 1918 deadly lethal flu
This enlivening of the 1918 flu virus
uncovered evidence of what made the microbe such a relentless killer --
it turns the body against itself and thus
managed to kill 50 million people worldwide.
While U.S. scientists collaborated on the
research, the scientists say the live 1918 virus will not leave the
Winnipeg lab. The U.S. version of the virus is stored in a federal lab in
Atlanta, Georgia, USA.
The Winnipeg lab is a "fortress within a
fortress" -- is designed for working on the most deadly pathogens in the
Some question the wisdom of resurrecting
extinct pathogens. U.S. microbiologist Richard Ebright, at Rutgers
University, says the 1918 virus should never have been recreated. He says
creating it again in Winnipeg increases the risk the virus could escape
and sets a "dangerous precedent" for other labs.
The research puts Canada's National
Microbiology Laboratory in Winnipeg on the map as the second place in the
world to resurrect the virus. U.S. scientists were the first to bring the
extinct virus to life in 2005.
CONTEXT OF TODAY'S NEWS STORY
PVAF is publishing this news story through its primary
mandate to spread knowledge among the entire humanity on this planet
Today's news story is the currently "hot" science of
genetics and Gnome research to find out why, what, how and when of creation
and sustenance of life......
And this current search for origin, meaning and purpose of
life through science is what the sciences of vED
is all about...vED is
left for humans in sNskRUt language which is only deciphered to about 10
percent, meaning 90 percent of the knowledge in
vED texts cannot be understood by the current humanity.
vED knowledge is highly complex sciences of life and creation
and is very
comprehensive and holistically interactive unlike current sciences which
have only recently started talking to each other.
One of the difficulty in
understand vED in its sNskRUt
language is its missing grammar. Presently the
sNskRUt vED texts are deciphered
mainly through the sNskRUt grammar
figured out by India's paaANini
circa 520–460 BC.
paaANini and composed in 3959
suuTR (aphorisms) in
aSHtaaDHyaayi (eight chapters). Even this
grammar is pretty difficult to understand as the use of the
vEDik sNskRUt language has been
lost for at least 5000 years now....
In vED any
creation from a stone to a highly complex living being such as man is
composed of two parts: an aat`maa (soul)
and the physical body in which the aatmaa resides, makes it
functional and controls...aat`maa
is eternal and keeps on taking new bodies when the current body
becomes old and/or dies...the successive bodies created and taken by
aat`maa itself are primary to partake
the kARm-fl (fruits of its
kARm performed in previous
lives).....and it is not a misprint - even a stone has an
The current science does not believe in metaphysics and
hence is constantly refusing to deal with aat`maa and deals with the
PVAF invites you to share your thoughts on a comparative
study of the knowledge of today's story and the
vED knowledge presented by Shrii
Champaklal Dajibhai Mistry of Edmonton, Alberta, Canada in this
right column from his vED library...Please
supplement this vED knowledge of
today with a vast amount of vED knowledge
that is contained in this web site....
And present your comparative study by
sharing it as your comment by clicking on the POST
A COMMENT button in the header of this news item....or
alternatively email your comparative study to PVAF for publication by
Please click on the next line to continue enlightening
yourself with in-depth understanding of knowledge of today's news story as it
could save you and the entire humanity one day with a pandemic similar to the
1918 flu which killed 50 million people in less than a year....that is just
about the same number of people killed in the second world war at a bombing and
bullet cost of trillions of dollars including all the destruction of buildings
and all made infrastructure needed for humans to live and sustain....the
flu virus did not spend any money: so where did it get all the power to destroy
50 million humans????!!!!!
Scientist unravel secret
deadly 1918 flu virus
turns body against itself
to drown the victim
Journal: CanWest News Service: January 18,
2007: Margaret Munro,
Scientists have resurrected the 1918 flu virus in Winnipeg,
Manitoba, Canada and uncovered evidence of what made the microbe such a
relentless killer -- it turns the body against itself.
In experiments that entailed infecting monkeys, the researchers have shown
the virus sends the immune systems into overdrive, flooding the lungs with
fluids that drown its victims. The scientists say this helps explain why so
many healthy young adults died as the 1918 flu pandemic swept the world
killing up to 50 million -- more people than died in the First World War.
The research also is expected to provide tips to halt future pandemics and
protect front-line workers.
"That's what this is all about," says Michael Katze of the
University of Washington in Seattle, a member of the international team that
describes the monkey experiments in the journal Nature, which is published
The research puts Canada's National Microbiology Laboratory in Winnipeg on
the map as the second place in the world to resurrect the virus. U.S.
scientists were the first to bring the extinct virus to life in 2005.
The Canadian virus was made using viral genes produced by Yoshihiro
Kawaoka's team at the University of Wisconsin-Madison.
The genes, replicas of DNA pulled from a woman who died of
the 1918 flu and was buried in Alaskan permafrost, were sent to the Level 4
biosafety lab in Winnipeg where Canadian researchers brought the virus to
"The procedure was not all that difficult," says Dr. Darwyn
Kobasa, a researcher
at the Manitoba lab. He says the eight carefully
crafted genes were inserted into cells along with a few proteins. Within
hours, the cells were taking instructions from the inserted genes and
mass-producing copies of the 1918 flu virus.
Last January, he and his colleagues produced millions of copies of the virus
in a bid to understand why the 1918 flu was so deadly. Ten macaque monkeys
from a breeding colony in Ottawa were used for the experiment.
Animal-care workers at the Winnipeg lab spent about two weeks working and
interacting with the animals before the experiment -- "so they'd get used to
seeing the people in the blue (biosafety) suits and begin interacting with
them," says Kelly Keith, communications manager for the lab.
On the day of the experiment the monkeys were put to sleep with anesthetic.
Three monkeys were exposed to conventional flu virus and seven to the 1918
virus. Flu-virus-laden solution was dripped into their noses, lungs and
eyes. Each one received an estimated seven million viruses. "It's never been
done before," says Kobasa, explaining why they used so many viruses to
The monkeys were kept under close observation after they awoke.
The animals exposed to conventional flu virus developed
symptoms but soon recovered. The animals exposed to the 1918 strain grew ill
and kept getting worse. Within days their lungs filled with fluid and blood
and they laboured to breathe.
The scientists intended to observe the animals for 21 days, but the monkeys
grew so ill, so fast, they were euthanized by day eight of the experiments.
"The idea is to stop the experiment before we cause a lot of stress and
trauma to the animals," says Kobasa. The experiment was approved by the
Canadian Council on Animal Care and officials at the Public Health Agency of
Canada, which is responsible the lab.
Tissues samples reveal that the 1918 virus caused the monkey's immune
systems to go haywire, pumping out large amounts of cytokines -- a so-called
cytokine storm, or a flood of compounds that can block airways and result in
suffocation -- that contributed to the disease's lethality.
In humans, the flu normally hits the elderly and children hardest. But in
1918 millions of 20- to 30-year-olds died. The researchers say their healthy
immune systems likely went into overdrive when confronted with the virus.
"Essentially, people are drowned," says Kawaoka.
It "sort of breaks the paradigm that one thinks of
the host response as always protective," says Katze.
The scientists are trying to tease out exactly what happens at the molecular
and genetic level.
They say the 1918 virus may hold clues to the next pandemic, which many fear
could be caused by the H5N1 bird virus if it starts to transmit from person
to person. "H5N1 virus can also cause very serious disease and it seems to
do this in a way that's quite similar to the 1918 virus," says Kobasa.
Some question the wisdom of resurrecting extinct pathogens. U.S.
microbiologist Richard Ebright, at Rutgers University, says the 1918 virus
should never have been recreated. He says creating it again in Winnipeg
increases the risk the virus could escape and sets a "dangerous precedent"
for other labs.
But many observers say the Winnipeg work is important.
"You have to be proactive, you have to work with the devil somewhat to
figure out what is going on," says virologist Earl Brown of the University
He says there are safety concerns, but the Winnipeg lab -- which Brown
describes as a "fortress within a fortress" -- is designed for working on
the most deadly pathogens.
And he says the research is paying off, given the "powerful" results. One of
the more intriguing revelations is that the virus did not stimulate a lot of
interferon production, which is normally one of the body's first lines of
"It looks like it was very stealthily moving through and not turning on
certain switches," says Brown.
Katze and Kawaoka argue that working with the 1918 flu in animals is
essential to prepare for future pandemics.
Should a pathogen, such as the 1918 virus, reappear, it would be critical to
know how the immune system would
respond and how to control unwanted reactions.
"One could imagine that the first responders -- the people on the front
lines in the hospital -- could perhaps be treated with a combination of
drugs, say antiviral drugs like Tamiflu and drugs that already exist to
control the inflammatory response," says Katze.
While U.S. scientists collaborated on the research, the scientists say
the live 1918 virus will not leave the Winnipeg lab. The U.S. version of the
virus is stored in a federal lab in Atlanta, Georgia, USA.
Kobasa says there are plans to infect more monkeys and other animals,
perhaps ferrets. He couldn't say whether the next round of experiments has
been approved, and the head of the Canadian work, Dr. Heinz Feldmann, was
unavailable for comment. Feldmann is in Kenya trying to contain an outbreak
of Rift Valley Fever.
Kobasa is matter-of-fact when asked what it is like to work with an organism
as lethal as the 1918 virus.
"Everyone is pretty well-trained and the protocols for working for the virus
are clear," he says. "We've done basically everything we can to minimize the
Before entering the level 4 biosafety lab, they strip off their street
clothes and put on a set of medical scrubs. Then they climb into bulky blue
rubber suits, complete with hood, clear face mask and self-contained
breathing system. They pull on yellow boots, snap on latex gloves and are
buzzed into the lab.
One the way out of the lab, they take a five-minute shower with a chemical
wash to decontaminate their blue suits. That's followed by a regular shower
that lasts at least three minutes.
Did Kobasa fear for his safety when he headed to the lab last January to
resurrect one of world's worst killers? "Not so much," he says.
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© The Edmonton Journal 2007
1918 flu virus triggers
overwhelming immune response
Globe and Mail:
Canadian Press: January 18, 2007
The virus that caused the 1918 influenza pandemic
triggered an overwhelming immune response that swamped the lungs of macaque
monkeys — the first primates deliberately infected with the Spanish flu
virus, Canadian and American scientists reported Wednesday.
The research, done in part at the Public Health Agency of Canada's National
Microbiology Laboratory in Winnipeg, supports the notion that the virulent
flu virus turned the body's immune system against itself. Scientists believe
that theory explains how the devastating influenza strain managed to mow
down unprecedented numbers of healthy people in the prime of life.
Previous work, done by some of the same scientists, showed mice infected
with the virus also experienced this hyper immune response, a so-called
cytokine storm. (Cytokines are one of the proteins the immune system makes
to fight infection.)
“There was an uncontrolled or aberrant inflammatory response,” one of the
authors, Dr. Michael Katze of the University of Washington in Seattle,
explained in a telephone briefing.
“One possibility (is) . . . instead of protecting the individuals that were
infected with the highly pathogenic virus, the immune response is actually
contributing to the lethality of the virus.”
Discovering how the Spanish flu, an H1N1 virus, killed an estimated 50
million people around the globe isn't an exercise in archeological
microbiology. Cracking the mysteries of highly virulent flu strains could
help the world prepare to battle the next bad influenza pandemic, said
Darwyn Kobasa, a research scientist with the Winnipeg lab and the first
author on the paper.
“Not only is the study of interest to understand what happened in 1918 but
it's also very relevant today as we possibly prepare for a new influenza
pandemic caused by an avian H5N1 virus,” said Mr. Kobasa, referring to the
highly pathogenic flu strain that for more than three years has been
decimating poultry flocks in parts of Asia and which has killed over 160
“The H5N1 virus can also cause very serious disease and it appears to do
this in a way that's quite similar to the 1918 virus. We think that a
greater understanding of the viruses that caused past pandemics will help us
predict what might be expected and how to plan to use our knowledge and
resources to reduce the impact of a new pandemic.”
|The research, published in the journal Nature, involved
an ambitious project to painstakingly recreate the 1918 virus — only the
second time this feat has been achieved. In 2005 scientists at the U.S.
Centers for Disease Control made history by becoming the first team to
recreate the virus.
The effort that led to this research began a
short time later. Yoshihiro Kawaoka, a leading influenza scientist working
at the University of Wisconsin, Madison, built each of the virus's eight
genes from scratch, using genetic blueprints housed in a public access
He then gave the plasmids — the pieces of DNA in which the genes were placed
— to scientists in Winnipeg. They then transferred or “transfected” the
genes into cell culture, allowing them to reassemble and grow in a process
called virus “rescue.”
The recreated virus was then used to infect seven macaques housed in a Level
4 laboratory in Winnipeg — the highest level of biosecurity available. The
monkeys became so ill they were euthanized after eight days, at which point
lung and other tissues were analyzed to chart the damage done.
Dr. Katze and his team in Seattle also traced the immunologic system
response by analyzing which immune proteins were produced when, and to what
Scientists hope that learning which parts of the immune system overreact to
this or other virulent flu viruses could provide clues as to how the process
could be interrupted and the damage lessened.
“It suggests if you interrupt the inflammatory chain in the innate immune
response, then you might have another tool in your armamentarium,” said Dr.
Anthony Fauci, director of the U.S. National Institute of Allergy and
Infectious Diseases and an expert in the workings of the immune system.
But while this work is a start, scientists still don't know how to dampen
down the immune response without then letting the virus continue to multiply
“If the result is, OK, you get less cytokines which will be good in terms of
immunopathology — but because of that you get also even higher levels of
virus replication which results in tissue damage, then you've solved one
problem but you come out with another one,” said Adolfo Garcia-Sastre, the
microbiologist at New York's Mt. Sinai Medical Center who played an
instrumental role in the first project to recreate the 1918 virus, but who
was not involved in this study.
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