SECRET OF CREATION OF LIFE: ....IT IS GENES.. BUT WHAT MAKES GENES COME ALIVE? 1918 FLU KILLING 50 MILLION PEOPLE REVEALS CREATION OF LIFE AND TAKING OF LIFE NEWS FLASH: In the second only of its kind laboratory in the world, the Canada's National Microbiology Laboratory in Winnipeg, Manitoba, with Level 4 biosafety certification, eight carefully crafted genes were inserted into cells along with a few proteins. Within hours, the cells were taking instructions from the inserted genes and mass-producing copies of the 1918 deadly lethal flu virus This enlivening of the 1918 flu virus uncovered evidence of what made the microbe such a relentless killer -- it turns the body against itself and thus managed to kill 50 million people worldwide. While U.S. scientists collaborated on the research, the scientists say the live 1918 virus will not leave the Winnipeg lab. The U.S. version of the virus is stored in a federal lab in Atlanta, Georgia, USA. The Winnipeg lab is a "fortress within a fortress" -- is designed for working on the most deadly pathogens in the world. Some question the wisdom of resurrecting extinct pathogens. U.S. microbiologist Richard Ebright, at Rutgers University, says the 1918 virus should never have been recreated. He says creating it again in Winnipeg increases the risk the virus could escape and sets a "dangerous precedent" for other labs. The research puts Canada's National Microbiology Laboratory in Winnipeg on the map as the second place in the world to resurrect the virus. U.S. scientists were the first to bring the extinct virus to life in 2005.     vEDIK CONTEXT OF TODAY'S NEWS STORY PVAF is publishing this news story through its primary mandate to spread knowledge among the entire humanity on this planet earth.... Today's news story is the currently "hot" science of genetics and Gnome research to find out why, what, how and when of creation and sustenance of life...... And this current search for origin, meaning and purpose of life through science is what the sciences of vED is all about...vED is left for humans in sNskRUt language which is only deciphered to about 10 percent, meaning 90 percent of the knowledge in vED texts cannot be understood by the current humanity. The vED knowledge is highly complex sciences of life and creation and is very comprehensive and holistically interactive unlike current sciences which have only recently started talking to each other. One of the difficulty in understand vED in its sNskRUt language is its missing grammar. Presently the sNskRUt vED texts are deciphered mainly through the sNskRUt grammar figured out by India's paaANini sometime circa 520–460 BC. paaANini and composed in 3959 suuTR (aphorisms)  in aSHtaaDHyaayi (eight chapters). Even this paaANini grammar is pretty difficult to understand as the use of the vEDik sNskRUt language has been lost for at least 5000 years now.... In vED any creation from a stone to a highly complex living being such as man is composed of two parts: an aat`maa (soul) and the physical body in which the aatmaa resides, makes it functional and controls...aat`maa is eternal and keeps on taking new bodies when the current body becomes old and/or dies...the successive bodies created and taken by aat`maa itself are primary to partake the kARm-fl (fruits of its kARm performed in previous lives).....and it is not a misprint - even a stone has an aat`maa....  The current science does not believe in metaphysics and hence is constantly refusing to deal with aat`maa and deals with the physical  bodies. PVAF invites you to share your thoughts on a comparative study of the knowledge of today's story and the vED knowledge presented by Shrii Champaklal Dajibhai Mistry of Edmonton, Alberta, Canada in this right column from his vED library...Please supplement this vED knowledge of  today with a vast amount of vED knowledge that is contained in this web site.... And present your comparative study by sharing it as your comment by clicking on the POST A COMMENT button in the header of this news item....or alternatively email your comparative study to PVAF for publication by clicking here.....   Please click on the next line to continue enlightening yourself with in-depth understanding of knowledge of today's news story as it could save you and the entire humanity one day with a pandemic similar to the 1918 flu which killed 50 million people in less than a year....that is just about the same number of people killed in the second world war at a bombing and bullet cost of trillions of dollars including all the destruction of buildings and all made infrastructure needed for humans to live and sustain....the flu virus did not spend any money: so where did it get all the power to destroy 50 million humans????!!!!!

Scientist unravel secret of deadly 1918 flu virus Relentless micro-killer turns body against itself to drown the victim Edmonton Journal: CanWest News Service: January 18, 2007: Margaret Munro, Scientists have resurrected the 1918 flu virus in Winnipeg, Manitoba, Canada and uncovered evidence of what made the microbe such a relentless killer -- it turns the body against itself. In experiments that entailed infecting monkeys, the researchers have shown the virus sends the immune systems into overdrive, flooding the lungs with fluids that drown its victims. The scientists say this helps explain why so many healthy young adults died as the 1918 flu pandemic swept the world killing up to 50 million -- more people than died in the First World War. The research also is expected to provide tips to halt future pandemics and protect front-line workers. "That's what this is all about," says Michael Katze of the University of Washington in Seattle, a member of the international team that describes the monkey experiments in the journal Nature, which is published today. The research puts Canada's National Microbiology Laboratory in Winnipeg on the map as the second place in the world to resurrect the virus. U.S. scientists were the first to bring the extinct virus to life in 2005. The Canadian virus was made using viral genes produced by Yoshihiro Kawaoka's team at the University of Wisconsin-Madison. The genes, replicas of DNA pulled from a woman who died of the 1918 flu and was buried in Alaskan permafrost, were sent to the Level 4 biosafety lab in Winnipeg where Canadian researchers brought the virus to life. "The procedure was not all that difficult," says Dr. Darwyn Kobasa,  a researcher at the Manitoba lab. He says the eight carefully crafted genes were inserted into cells along with a few proteins. Within hours, the cells were taking instructions from the inserted genes and mass-producing copies of the 1918 flu virus. Last January, he and his colleagues produced millions of copies of the virus in a bid to understand why the 1918 flu was so deadly. Ten macaque monkeys from a breeding colony in Ottawa were used for the experiment. Animal-care workers at the Winnipeg lab spent about two weeks working and interacting with the animals before the experiment -- "so they'd get used to seeing the people in the blue (biosafety) suits and begin interacting with them," says Kelly Keith, communications manager for the lab. On the day of the experiment the monkeys were put to sleep with anesthetic. Three monkeys were exposed to conventional flu virus and seven to the 1918 virus. Flu-virus-laden solution was dripped into their noses, lungs and eyes. Each one received an estimated seven million viruses. "It's never been done before," says Kobasa, explaining why they used so many viruses to ensure infection. The monkeys were kept under close observation after they awoke. The animals exposed to conventional flu virus developed symptoms but soon recovered. The animals exposed to the 1918 strain grew ill and kept getting worse. Within days their lungs filled with fluid and blood and they laboured to breathe. The scientists intended to observe the animals for 21 days, but the monkeys grew so ill, so fast, they were euthanized by day eight of the experiments. "The idea is to stop the experiment before we cause a lot of stress and trauma to the animals," says Kobasa. The experiment was approved by the Canadian Council on Animal Care and officials at the Public Health Agency of Canada, which is responsible the lab. Tissues samples reveal that the 1918 virus caused the monkey's immune systems to go haywire, pumping out large amounts of cytokines -- a so-called cytokine storm, or a flood of compounds that can block airways and result in suffocation -- that contributed to the disease's lethality.   In humans, the flu normally hits the elderly and children hardest. But in 1918 millions of 20- to 30-year-olds died. The researchers say their healthy immune systems likely went into overdrive when confronted with the virus. "Essentially, people are drowned," says Kawaoka. It "sort of breaks the paradigm that one thinks of the host response as always protective," says Katze. The scientists are trying to tease out exactly what happens at the molecular and genetic level. They say the 1918 virus may hold clues to the next pandemic, which many fear could be caused by the H5N1 bird virus if it starts to transmit from person to person. "H5N1 virus can also cause very serious disease and it seems to do this in a way that's quite similar to the 1918 virus," says Kobasa. Some question the wisdom of resurrecting extinct pathogens. U.S. microbiologist Richard Ebright, at Rutgers University, says the 1918 virus should never have been recreated. He says creating it again in Winnipeg increases the risk the virus could escape and sets a "dangerous precedent" for other labs. But many observers say the Winnipeg work is important. "You have to be proactive, you have to work with the devil somewhat to figure out what is going on," says virologist Earl Brown of the University of Ottawa. He says there are safety concerns, but the Winnipeg lab -- which Brown describes as a "fortress within a fortress" -- is designed for working on the most deadly pathogens. And he says the research is paying off, given the "powerful" results. One of the more intriguing revelations is that the virus did not stimulate a lot of interferon production, which is normally one of the body's first lines of defence. "It looks like it was very stealthily moving through and not turning on certain switches," says Brown. Katze and Kawaoka argue that working with the 1918 flu in animals is essential to prepare for future pandemics. Should a pathogen, such as the 1918 virus, reappear, it would be critical to know how the immune system would respond and how to control unwanted reactions. "One could imagine that the first responders -- the people on the front lines in the hospital -- could perhaps be treated with a combination of drugs, say antiviral drugs like Tamiflu and drugs that already exist to control the inflammatory response," says Katze. While U.S. scientists collaborated on the research, the scientists say the live 1918 virus will not leave the Winnipeg lab. The U.S. version of the virus is stored in a federal lab in Atlanta, Georgia, USA. Kobasa says there are plans to infect more monkeys and other animals, perhaps ferrets. He couldn't say whether the next round of experiments has been approved, and the head of the Canadian work, Dr. Heinz Feldmann, was unavailable for comment. Feldmann is in Kenya trying to contain an outbreak of Rift Valley Fever. Kobasa is matter-of-fact when asked what it is like to work with an organism as lethal as the 1918 virus. "Everyone is pretty well-trained and the protocols for working for the virus are clear," he says. "We've done basically everything we can to minimize the risk." Before entering the level 4 biosafety lab, they strip off their street clothes and put on a set of medical scrubs. Then they climb into bulky blue rubber suits, complete with hood, clear face mask and self-contained breathing system. They pull on yellow boots, snap on latex gloves and are buzzed into the lab. One the way out of the lab, they take a five-minute shower with a chemical wash to decontaminate their blue suits. That's followed by a regular shower that lasts at least three minutes. Did Kobasa fear for his safety when he headed to the lab last January to resurrect one of world's worst killers? "Not so much," he says. Email to a friend © The Edmonton Journal 2007   1918 flu virus triggers overwhelming immune response Globe and Mail: Canadian Press: January 18, 2007 The virus that caused the 1918 influenza pandemic triggered an overwhelming immune response that swamped the lungs of macaque monkeys — the first primates deliberately infected with the Spanish flu virus, Canadian and American scientists reported Wednesday. The research, done in part at the Public Health Agency of Canada's National Microbiology Laboratory in Winnipeg, supports the notion that the virulent flu virus turned the body's immune system against itself. Scientists believe that theory explains how the devastating influenza strain managed to mow down unprecedented numbers of healthy people in the prime of life. Previous work, done by some of the same scientists, showed mice infected with the virus also experienced this hyper immune response, a so-called cytokine storm. (Cytokines are one of the proteins the immune system makes to fight infection.) “There was an uncontrolled or aberrant inflammatory response,” one of the authors, Dr. Michael Katze of the University of Washington in Seattle, explained in a telephone briefing. “One possibility (is) . . . instead of protecting the individuals that were infected with the highly pathogenic virus, the immune response is actually contributing to the lethality of the virus.” Discovering how the Spanish flu, an H1N1 virus, killed an estimated 50 million people around the globe isn't an exercise in archeological microbiology. Cracking the mysteries of highly virulent flu strains could help the world prepare to battle the next bad influenza pandemic, said Darwyn Kobasa, a research scientist with the Winnipeg lab and the first author on the paper. “Not only is the study of interest to understand what happened in 1918 but it's also very relevant today as we possibly prepare for a new influenza pandemic caused by an avian H5N1 virus,” said Mr. Kobasa, referring to the highly pathogenic flu strain that for more than three years has been decimating poultry flocks in parts of Asia and which has killed over 160 people. “The H5N1 virus can also cause very serious disease and it appears to do this in a way that's quite similar to the 1918 virus. We think that a greater understanding of the viruses that caused past pandemics will help us predict what might be expected and how to plan to use our knowledge and resources to reduce the impact of a new pandemic.”   The research, published in the journal Nature, involved an ambitious project to painstakingly recreate the 1918 virus — only the second time this feat has been achieved. In 2005 scientists at the U.S. Centers for Disease Control made history by becoming the first team to recreate the virus.   The effort that led to this research began a short time later. Yoshihiro Kawaoka, a leading influenza scientist working at the University of Wisconsin, Madison, built each of the virus's eight genes from scratch, using genetic blueprints housed in a public access database. He then gave the plasmids — the pieces of DNA in which the genes were placed — to scientists in Winnipeg. They then transferred or “transfected” the genes into cell culture, allowing them to reassemble and grow in a process called virus “rescue.” The recreated virus was then used to infect seven macaques housed in a Level 4 laboratory in Winnipeg — the highest level of biosecurity available. The monkeys became so ill they were euthanized after eight days, at which point lung and other tissues were analyzed to chart the damage done. Dr. Katze and his team in Seattle also traced the immunologic system response by analyzing which immune proteins were produced when, and to what levels. Scientists hope that learning which parts of the immune system overreact to this or other virulent flu viruses could provide clues as to how the process could be interrupted and the damage lessened. “It suggests if you interrupt the inflammatory chain in the innate immune response, then you might have another tool in your armamentarium,” said Dr. Anthony Fauci, director of the U.S. National Institute of Allergy and Infectious Diseases and an expert in the workings of the immune system. But while this work is a start, scientists still don't know how to dampen down the immune response without then letting the virus continue to multiply unchecked. “If the result is, OK, you get less cytokines which will be good in terms of immunopathology — but because of that you get also even higher levels of virus replication which results in tissue damage, then you've solved one problem but you come out with another one,” said Adolfo Garcia-Sastre, the microbiologist at New York's Mt. Sinai Medical Center who played an instrumental role in the first project to recreate the 1918 virus, but who was not involved in this study. Print E-mail Comments (12) Share this article

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