BIOLOGICAL BODY scientific discovery says they can be used to treat human diseases.....
Posted by Vishva News Reporter on February 22, 2010


........BREAKING NEWS....

.....A new discovery about
how our internal body clocks functions
could lead to treatment of
sleep disorders, jet lag, cancers, and Alzheimer’s disease....

.....according to journal Science dated October 8, 2009..
researchers from the United States and United Kingdom and
mathematicians from the University of Michigan and University of Manchester
who derived the findings from a two-year study of
a variety of computer-generated mathematics equations..

They also say....
these internal body clocks may be ticking more
to their own circadian rhythms than originally believed....

......the decades-old theory of how the brain sends signals
to the rest of the body through an internal clock is inaccurate.....


.....the more you know about
.....the more happier you can live
today and tomorrow with that life knowledge...

Ancient Greeks used to inscribe
on entrances of their human healing centers
dream incubation centers
used for healing human bodies......

aayuARvED, the medical sciences in the entire corpus of
life sciences called vED says

"KNOW YOUR aatmaa (soul)

of all of YOUR sufferings through diseases/disorders caused by causes
called in sNskRUt language of vED
(caused by
your aatmaa which is by shroud of paapi kARm-fl is not free to walk its
vEDik life path and causes psychological disorders/diseases )
caused by 33 kror = 330 million DEvtaao who are natural forces and powers
which operate and sustain your body
but who become dysfunctional through
breakdown in your vEDik DHARm relationship with them)

(any fellow creations from humans, animals, plant life and micro-organisms
who go against you for infinite enmity reasons including
paapi kARm-fl or you not treating them as per vEDik DHARm of
 harmonious inter-dependency co-existence as per the design of the Creator )

(contributed by Champaklal Dajibhai Mistry of Edmonton, Canada
as a sharing from his daily vED study and vED library...)
.....NOW KNOW THAT....


centered in a group of cells in the hypothalamus and operated by


.....which operates clocks, called peripheral oscillators,
 found in your
 esophagus, lung, liver, pancreas, spleen, thymus, and the skin....


.....Circadian Rhythms Affects Our
Metabolism, Mood, Sleep, &
Eating, Medication and All Daily Life Functions and Patterns....

File:Biological clock human.PNG

Overview of human circadian biological clock
with some physiological parameters

.....Circadian Rhythms Affects Our
METABOLISM, Mood, Sleep, & Eating Patterns....

A circadian rhythm is a roughly-24-hour cycle in the biochemical, physiological or behavioral processes of living entities, including plants, animals, fungi and cyanobacteria (see bacterial circadian rhythms). The term "circadian", coined by Franz Halberg, comes from the Latin circa, "around," and diem or dies, "day", meaning literally "approximately one day." The formal study of biological temporal rhythms such as daily, tidal, weekly, seasonal, and annual rhythms, is called chronobiology. Circadian rhythms are endogenously generated, and can be entrained by external cues, called zeitgebers, the primary one of which is daylight. These rhythms allow organisms to anticipate and prepare for precise and regular environmental changes.

The earliest known account of a circadian rhythm dates from the 4th century BC, when Androsthenes, a ship captain serving under Alexander the Great, described diurnal leaf movements of the tamarind tree. The first modern observation of endogenous circadian oscillation was by the French scientist Jean-Jacques d'Ortous de Mairan in the 1700s; he noted that 24-hour patterns in the movement of the leaves of the plant Mimosa pudica continued even when the plants were isolated from external stimuli. In 1918, J. S. Szymanski showed that animals are capable of maintaining 24-hour activity patterns in the absence of external cues such as light and changes in temperature. Joseph Takahashi discovered the genetic basis for the mammalian circadian rhythm in 1994....

....To continue studying through Wikipedia, the free on-line overview of the preceding human body knowledge on biological clocks that operate human body systems and also body systems of all living beings.... please click here.......

.....This Wikipedia overview will empower YOU to understand today's sharing of the latest scientific research news on the next web page... about the newly discovered understanding of the human body clock working on daily 24-hour circadian rhythm.... which could lead to advanced treating many human diseases....... 

......and to read this new research news ...
along with 2008 research showing
half of our genes controlled by our biological clock and
a study linking diabetes to body
some research knowledge on sciences of
circadian rhythm,
biological clock and
their effects on human health
please click on the next line



.........BREAKING NEWS.....

........Body clock research
can treat diseases

(From: Edmonton Journal: 9 October, 2009: CanWest News Service)
 A new discovery about how our internal body clocks function could lead to treatment of sleep disorders, jet lag — even cancers and Alzheimer’s disease, according to researchers from the United States and United Kingdom.

They also say these clocks may be ticking more to their own circadian rhythms than originally believed.

In a study published Thursday in the journal Science, mathematicians from the University of Michigan and University of Manchester say the decades-old theory of how the brain sends signals to the rest of the body through an internal clock is inaccurate.

It was believed that an internal body clock operated by quickly emitting neurons to the body during the day, and slowing down the number of neurons sent at night. This change in pace presumably allowed the body to keep track of time.

But one of the study’s authors, Daniel Forger, said new research has found that the neurons actually remain at an elevated “excited state,” but do not fire during the day or night. Instead, the neurons are only fired for brief periods around dusk and dawn.

“This group of neurons in the brain act as a general pacemaker for humans,” said Forger, an associate professor of mathematics at the University of Michigan. “It co-ordinates timing throughout the body.”

Neurons are excitable cells in the nervous system that process and transmit information by electrochemical signaling. Neurons are the core components of the brain and the spinal cord.

Forger said this discovery will lead to a greater understanding of how one’s internal body clock is affected by jet lag, insomnia and shift work. It may also affect research into cancers, seasonal affective disorder, blood pressure and Alzheimer’s.

For instance, some studies have shown that chemotherapy for cancer patients is more effective during certain times of the day, said Forger.

The findings were derived from a two-year study of a variety of computer-generated mathematics equations.

.......and now read....

University of Georgia researchers show
for the first time that
dramatically more genes
are controlled by biological clocks
than previously known

(From RESEARCH NEWS AND FACTS WEB SITE: August 29, 2008: Athens, Georgia. USA
Writer: Philip Lee Williams, 706/542-8501,
Contact: Jonathan Arnold, 706/542-1449,

 The tick-tock of your biological clock may have just gotten a little louder.

Researchers at the University of Georgia report that the number of genes under control of the biological clock in a much-studied model organism is dramatically higher than previously reported. The new study implies that the clock may be much more important in living things than suspected only a few years ago.

“This new finding may help to explain why the clock is so far-reaching in its effects on the organism,” said Jonathan Arnold, a professor in the UGA department of genetics and director of the research project. “We found that some 25 percent of the genes in our model organism appear to be under clock control. I wasn’t suspecting anything remotely like that.”

The new research, just published in the Public Library of Science One, also shows how Arnold’s team used a new methodology called Computing Life to yield these new discoveries about biological clocks. And this tool of systems biology was the key to showing what makes a biological clock tick.

In addition to Arnold, authors of the paper include Wubei Dong, James Griffith, Roger Nielsen and Rosemary Kim in the department of genetics, and Xiaojia Tang, Yihai Yu and Bernd Schuttler of the department of physics and astronomy. Griffith also has an appointment in the College of Environmental and Agricultural Sciences. The department of genetics is in the Franklin College of Arts and Sciences.

The team’s new discoveries about the extent of genes under the control of the biological clock and the utility of Computing Life came from studying genes in Neurospora crassa—bread mold. In fact, much of what science knows about biological clocks has come from studying Neurospora.

Before the current research, only 16 clock-controlled genes had been discovered in Neurospora in more than 40 years of research. Arnold’s team uncovered a remarkable 295 genes that are influenced by the biological clock—and that number could be dramatically higher, given the conservative controls the researchers put on their work.

“It appears the clock influences a number of biological processes, including cell cycling, protein metabolism and varied signaling processes,” said Arnold. “But perhaps the most important role we’ve seen so far is the clock’s role in ribosome biogenesis.”

Ribosomes assemble individual amino acids into polypeptide chains by binding a messenger RNA and then using this as a template to connect the correct sequence of amino acids. Ribosome biogenesis is the process of making ribosomes, so knowledge that the process is under clock control adds a dramatic new dimension to the clock’s inherent biological value as an adaptation.

The new Computing Life technology, refined in the Arnold and Schuttler labs, integrates several cycles of modeling and experiments to yield discoveries about a genetic network. Using Computing Life, the scientists were able to unravel how a network of genes and their products tell time, thereby demonstrating the solution of one of the key problems in systems biology.

“The resulting molecular mechanism or genetic network for the clock identified by this mode-guided discovery process will have a broad appeal to geneticists, physiologists and those with an interest in signaling pathways,” said Arnold. “The methods used to characterize what makes a biological clock tick will have numerous applications in finding genetic networks describing other complex traits in many biological systems.”

Computing Life will also allow researchers to design a sequence of genomics experiments that will winnow the field of competing hypotheses and to move experiments in directions where new discoveries are likely to arise.

Biological clocks hold the key to much of life and disease processes. In February 2007, Arnold’s team reported in the Proceedings of the National Academy of Sciences the first working model that explains how biological clocks operate. The UGA scientists discovered how three genes in Neurospora make such a clock tick at the molecular level.

That discovery also had broad implications for understanding biochemical signaling and other regulatory processes in cells, Arnold said.

Writers: A copy of the PLoS One paper described in this story is available from Arnold. Please contact him through the e-mail address at the top of this article.

.......Body clock linked to
diabetes and high blood sugar
in new study......

(from bio-medicine web site: December 7, 2008)
Diabetes and high levels of blood sugar may be linked to abnormalities in a person's body clock and sleep patterns, according to a genome-wide association study published today in the journal Nature Genetics.

The research suggests that diabetes and higher than normal blood sugar levels could partly be tackled by treating  sleep problems, say the researchers, from Imperial College London, the French National Research Institute CNRS, Lille University, McGill University in Canada, Steno Diabetes Centre in Denmark and other international institutions.

People with high blood sugar levels and diabetes have a greatly increased risk of developing a range of conditions, including cardiovascular diseases.

The new study shows that a mutation called rs1387153, near a gene called MTNR1B, is associated with having an increased average blood sugar level and around a 20 percent elevated risk of developing type 2 diabetes.

MTNR1B forms part of a signaling pathway that controls the action of the hormone melatonin. This hormone regulates the body's  circadian rhythm - the internal clock that controls sleeping and eating patterns by responding to daylight and darkness.

The discovery of the rs1387153 mutation provides evidence that high blood sugar and diabetes could be directly linked to an impaired circadian rhythm.

Professor Philippe Froguel, the corresponding author of the research from the Department of Genomic Medicine at Imperial College London, said: "There is already some research to suggest there are links between sleep problems and conditions such as obesity and depression, both of which are associated with diabetes. For example, we know that obese children tend to sleep badly and that people become more obese if they are not having enough sleep. Our new study demonstrates that abnormalities in the circadian rhythm may partly be causing diabetes and high blood sugar levels. 

Contact: Laura Gallagher
Imperial College London




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