|BIOLOGICAL BODY CLOCKS....new scientific discovery says they can be used to treat human diseases.....|
Posted by Vishva News Reporter on February 22, 2010
.....A new discovery about
how our internal body clocks functions
could lead to treatment of
sleep disorders, jet lag, cancers, and Alzheimer’s disease....
.....according to journal
Science dated October 8,
researchers from the United States and United Kingdom and
mathematicians from the University of Michigan and University of
who derived the findings from a two-year study of
a variety of computer-generated mathematics equations..
They also say.....
these internal body clocks may be ticking more
to their own circadian
rhythms than originally believed....
decades-old theory of how the brain sends signals
to the rest of the
body through an internal clock is inaccurate.....
......THIS NEWS SHARING IS CONTINUING PART OF
PVAF'S "KNOW THYSELF" SERIES...
.....the more you know about
YOURSELF AS LIFE.....
.....the more happier you can live
today and tomorrow with that life knowledge...
Ancient Greeks used to inscribe
on entrances of their human healing
dream incubation centers
used for healing human bodies......
aayuARvED, the medical
sciences in the entire corpus of
life sciences called vED
"KNOW YOUR aatmaa (soul)
YOU WILL EMPOWER WITH SELF-KNOWLEDGE
TO HEAL YOURSELF"
of all of YOUR sufferings through diseases/disorders
caused by causes
called in sNskRUt
language of vED
aatmaa which is by
shroud of paapi kARm-fl
is not free to walk its
vEDik life path and causes
psychological disorders/diseases ),
kror = 330
who are natural forces and powers
which operate and sustain your body
but who become dysfunctional through
breakdown in your vEDik DHARm
relationship with them)
creations from humans, animals, plant life and micro-organisms
who go against you for infinite enmity reasons including
paapi kARm-fl or you not treating
them as per vEDik
harmonious inter-dependency co-existence as per the design of the Creator
Champaklal Dajibhai Mistry of
as a sharing from his daily vED
study and vED
.....NOW KNOW THAT....
........YOUR BODY HAS ITS
centered in a group of
cells in the hypothalamus and operated by
NATURE'S CIRCADIAN RHYTHM.....
.....which operates clocks, called peripheral oscillators,
found in your
esophagus, lung, liver, pancreas, spleen, thymus, and the skin....
.......AND MOST OF LIVING BEINGS
LIVE BY THE SAME
CIRCADIAN RHYTHM OPERATED BODY
.....Circadian Rhythms Affects Our
Metabolism, Mood, Sleep, &
Eating, Medication and All Daily Life Functions and Patterns....
Overview of human circadian
with some physiological parameters
.....Circadian Rhythms Affects Our
METABOLISM, Mood, Sleep, & Eating Patterns....
circadian rhythm is a
roughly-24-hour cycle in the biochemical, physiological or behavioral
processes of living entities, including
bacterial circadian rhythms).
The term "circadian", coined by
comes from the
"around," and diem
"day", meaning literally "approximately one day." The formal study of
biological temporal rhythms such as daily,
weekly, seasonal, and annual rhythms, is called
Circadian rhythms are
generated, and can be entrained by external cues, called
the primary one of which is
These rhythms allow organisms to anticipate and prepare for precise and
regular environmental changes.
The earliest known account of a
circadian rhythm dates from the 4th century BC, when Androsthenes, a
ship captain serving under
Alexander the Great,
leaf movements of the
tree. The first modern
observation of endogenous circadian oscillation was by the French
Jean-Jacques d'Ortous de Mairan
in the 1700s; he noted that 24-hour patterns in the movement of the
leaves of the plant
continued even when the plants were isolated from external stimuli. In
1918, J. S. Szymanski showed that animals are capable of maintaining
24-hour activity patterns in the absence of external cues such as light
and changes in temperature.
discovered the genetic basis for the mammalian circadian rhythm in
....To continue studying through Wikipedia, the free on-line
encyclopedia....an overview of the preceding human body knowledge on
biological clocks that operate human body systems and also body systems
of all living beings.... please click
.....This Wikipedia overview will empower YOU to understand today's sharing of the latest
scientific research news on the next web page... about the newly
discovered understanding of the human body clock working on daily
24-hour circadian rhythm.... which could lead to advanced treating many
......and to read this new research news ...
along with 2008 research showing
half of our genes controlled by our biological clock and
a study linking diabetes to body clock..plus
some research knowledge on
biological clock and
their effects on human health....
please click on the next line
........Body clock research
can treat diseases....
9 October, 2009: CanWest News Service)
| A new discovery about how our internal
body clocks function could lead to treatment of sleep disorders, jet lag
— even cancers and Alzheimer’s disease, according to researchers from
the United States and United Kingdom.
They also say these clocks may be ticking more to their own circadian
rhythms than originally believed.
In a study published Thursday in the journal Science, mathematicians
from the University of Michigan and University of Manchester say the
decades-old theory of how the brain sends signals to the rest of the
body through an internal clock is inaccurate.
It was believed that an internal body clock operated by quickly emitting
neurons to the body during the day, and slowing down the number of
neurons sent at night. This change in pace presumably allowed the body
to keep track of time.
But one of the study’s authors, Daniel Forger, said new research has
found that the neurons actually remain at an elevated “excited state,”
but do not fire during the day or night. Instead, the neurons are only
fired for brief periods around dusk and dawn.
“This group of neurons in the brain act as a general pacemaker for
humans,” said Forger, an associate professor of mathematics at the
University of Michigan. “It co-ordinates timing throughout the body.”
Neurons are excitable cells in the nervous system that process and
transmit information by electrochemical signaling. Neurons are the core
components of the brain and the spinal cord.
Forger said this discovery will lead to a greater understanding of how
one’s internal body clock is affected by jet lag, insomnia and shift
work. It may also affect research into cancers, seasonal affective
disorder, blood pressure and Alzheimer’s.
For instance, some studies have shown that chemotherapy for cancer
patients is more effective during certain times of the day, said Forger.
The findings were derived from a two-year study of a variety of
computer-generated mathematics equations.
University of Georgia researchers show
for the first time that
dramatically more genes
controlled by biological clocks
than previously known
RESEARCH NEWS AND FACTS WEB SITE:
August 29, 2008: Athens, Georgia. USA
Writer: Philip Lee Williams, 706/542-8501, email@example.com
Contact: Jonathan Arnold, 706/542-1449, firstname.lastname@example.org)
The tick-tock of your biological clock may have just gotten a little
Researchers at the University of Georgia report that the number of genes
under control of the biological clock in a much-studied model organism
is dramatically higher than previously reported. The new study implies
that the clock may be much more important in living things than
suspected only a few years ago.
“This new finding may help to explain why the clock is so far-reaching
in its effects on the organism,” said Jonathan Arnold, a professor in
the UGA department of genetics and director of the research project. “We
found that some 25 percent of the genes in our model organism appear to
be under clock control. I wasn’t suspecting anything remotely like
The new research, just published in the Public Library of Science One,
also shows how Arnold’s team used a new methodology called Computing
Life to yield these new discoveries about biological clocks. And this
tool of systems biology was the key to showing what makes a biological
In addition to Arnold, authors of the paper include Wubei Dong, James
Griffith, Roger Nielsen and Rosemary Kim in the department of genetics,
and Xiaojia Tang, Yihai Yu and Bernd Schuttler of the department of
physics and astronomy. Griffith also has an appointment in the College
of Environmental and Agricultural Sciences. The department of genetics
is in the Franklin College of Arts and Sciences.
The team’s new discoveries about the extent of genes under the control
of the biological clock and the utility of Computing Life came from
studying genes in Neurospora crassa—bread mold. In fact, much of what
science knows about biological clocks has come from studying Neurospora.
Before the current research, only 16 clock-controlled genes had been
discovered in Neurospora in more than 40 years of research. Arnold’s
team uncovered a remarkable 295 genes that are influenced by the
biological clock—and that number could be dramatically higher, given the
conservative controls the researchers put on their work.
“It appears the clock influences a number of biological processes,
including cell cycling, protein metabolism and varied signaling
processes,” said Arnold. “But perhaps the most important role we’ve seen
so far is the clock’s role in ribosome biogenesis.”
Ribosomes assemble individual amino acids into polypeptide chains by
binding a messenger RNA and then using this as a template to connect the
correct sequence of amino acids. Ribosome biogenesis is the process of
making ribosomes, so knowledge that the process is under clock control
adds a dramatic new dimension to the clock’s inherent biological value
as an adaptation.
The new Computing Life technology, refined in the Arnold and Schuttler
labs, integrates several cycles of modeling and experiments to yield
discoveries about a genetic network. Using Computing Life, the
scientists were able to unravel how a network of genes and their
products tell time, thereby demonstrating the solution of one of the key
problems in systems biology.
“The resulting molecular mechanism or genetic network for the clock
identified by this mode-guided discovery process will have a broad
appeal to geneticists, physiologists and those with an interest in
signaling pathways,” said Arnold. “The methods used to characterize what
makes a biological clock tick will have numerous applications in finding
genetic networks describing other complex traits in many biological
Computing Life will also allow researchers to design a sequence of
genomics experiments that will winnow the field of competing hypotheses
and to move experiments in directions where new discoveries are likely
Biological clocks hold the key to much of life and disease processes. In
February 2007, Arnold’s team reported in the Proceedings of the National
Academy of Sciences the first working model that explains how biological
clocks operate. The UGA scientists discovered how three genes in
Neurospora make such a clock tick at the molecular level.
That discovery also had broad implications for understanding biochemical
signaling and other regulatory processes in cells, Arnold said.
Writers: A copy of the
PLoS One paper described in this story is available from Arnold. Please
contact him through the e-mail address at the top of this article.
.......Body clock linked to
diabetes and high blood sugar
in new study......
bio-medicine web site:
December 7, 2008)
|Diabetes and high levels of blood sugar may be linked to
abnormalities in a person's
clock and sleep patterns, according to a genome-wide
association study published today in the journal Nature Genetics.
The research suggests that diabetes and higher than normal blood sugar
levels could partly be tackled by
treating sleep problems, say the researchers, from Imperial
College London, the French National Research Institute CNRS, Lille
University, McGill University in Canada, Steno Diabetes Centre in
Denmark and other international institutions.
People with high blood sugar levels and diabetes have a greatly
increased risk of developing a range of conditions, including
The new study shows that a mutation called rs1387153, near a gene called
MTNR1B, is associated with having an increased average blood sugar level
and around a 20 percent elevated risk of developing type 2 diabetes.
MTNR1B forms part of a signaling pathway that controls the action of the
hormone melatonin. This hormone regulates the
body's circadian rhythm - the internal clock that
controls sleeping and eating patterns by responding to daylight and
The discovery of the rs1387153 mutation provides evidence that high
blood sugar and diabetes could be directly linked to an impaired
Professor Philippe Froguel, the corresponding author of the research
from the Department of Genomic Medicine at Imperial College London,
said: "There is already some research to suggest there are links between
sleep problems and conditions such as obesity and depression, both of
which are associated with diabetes. For example, we know that obese
children tend to sleep badly and that people become more obese if they
are not having enough sleep. Our new study demonstrates that
abnormalities in the circadian rhythm may partly be causing diabetes and
high blood sugar levels.
Contact: Laura Gallagher
Imperial College London
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